首页> 外文OA文献 >TOLERANCE DEVELOPMENT TO THE EFFECTS OF ETHANOL: ROLE OF BEHAVIORAL THERMOREGULATORY RESPONSES (BODY TEMPERATURE, CLASSICAL CONDITIONING, OPERANT LEARNING).
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TOLERANCE DEVELOPMENT TO THE EFFECTS OF ETHANOL: ROLE OF BEHAVIORAL THERMOREGULATORY RESPONSES (BODY TEMPERATURE, CLASSICAL CONDITIONING, OPERANT LEARNING).

机译:对乙醇作用的耐受性发展:行为热调节反应的作用(体温,经典条件,操作学习)。

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摘要

The mechanisms which account for the diminished responsiveness (tolerance) of an individual to a drug, as a result of prior exposure to that drug, are not yet fully understood. Recently, it has been suggested that drug tolerance is a learned adaptive response. This possibility was examined by studying the effect of ethanol on body temperature and behavioral thermoregulatory responses of Sprague-Dawley rats. Two major studies were conducted. The first study examined the initial dose-related effects of ethanol (1, 2, or 3 g/kg i.p.); the second study examined the effect of ethanol (2.5 g/kg i.p.) administered on 14 consecutive days. Rats were tested in a thermocline, a hollo plexiglass tube in which a linear temperature gradient (6-36°C) was established through local heating and cooling of opposite ends of the tube. The position of rats in the thermocline was detected by a series of infrared light emitting diodes and photocells. The body temperature of rats in the thermocline was transmitted by a temperature sensitive telemetry capsule surgically placed in the peritoneal cavity. Validation studies demonstrated that rats reliably responded to temperature cues within the thermocline. In the first experiment ethanol produced a dose-related decrease in body temperature. All rats following injection initially selected an ambient temperature cooler than baseline. Rats receiving control treatment or the high dose of ethanol eventually shifted to a warmer ambient temperature. Activity levels were depressed equally by all three doses of ethanol. In the second experiment tolerance developed to the hypothermic effect of ethanol. A diminished response to ethanol was evident by the second test day and was maximal by day 7. Ethanol treated rats selected a cooler ambient temperature than control rats throughout the 14 day period, and activity levels continued to be depressed by ethanol throughout the 14 days. On the fifteenth day all rats were given an injection of saline. Rats which had previously received daily ethanol injections exhibited a hyperthermic response to saline compared to control rats. These results suggest that ethanol altered the central control of thermoregulation by lowering and possibly broadening the thermoregulatory set point. There was evidence for a conditioned hyperthermic response, but not a learned behavioral response, which contributed to the tolerance development.
机译:尚未完全了解导致个体对药物的反应性(耐受性)降低的机制,该机制是由于事先接触该药物而导致的。最近,已经提出药物耐受性是习得的适应性反应。通过研究乙醇对Sprague-Dawley大鼠的体温和行为体温调节反应的影响,检验了这种可能性。进行了两项主要研究。第一项研究检查了乙醇的初始剂量相关效应(1、2、3 g / kg i.p.)。第二项研究检查了连续14天服用乙醇(2.5 g / kg i.p.)的效果。将大鼠放在温热有机玻璃中空管中进行测试,其中通过局部加热和冷却管的相对两端来建立线性温度梯度(6-36°C)。通过一系列红外发光二极管和光电管检测大鼠在温跃层中的位置。高温下大鼠的体温通过外科手术放置在腹膜腔中的温度敏感遥测胶囊传输。验证研究表明,大鼠对温跃层内的温度线索有可靠的反应。在第一个实验中,乙醇使体温与剂量有关。注射后,所有大鼠最初选择的环境温度比基线低。接受对照治疗或高剂量乙醇的大鼠最终转变为较温暖的环境温度。所有三种剂量的乙醇均使活性水平降低。在第二个实验中,对乙醇的低温效应产生了耐受性。在第二个测试日对乙醇的反应减弱,并且在第7天达到最大。在14天的时间段内,用乙醇处理的大鼠选择的环境温度比对照大鼠低,并且在整个14天内,乙醇的活性水平持续降低。在第15天,给所有大鼠注射盐水。与对照大鼠相比,先前每天接受乙醇注射的大鼠表现出对盐水的高温反应。这些结果表明,乙醇通过降低并可能加宽了温度调节设定点来改变温度调节的中央控制。有证据表明有条件的高温反应,但不是习得的行为反应,这有助于耐受性的发展。

著录项

  • 作者

    SPENCER ROBERT LEON.;

  • 作者单位
  • 年度 1986
  • 总页数
  • 原文格式 PDF
  • 正文语种 en
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