首页> 外文OA文献 >A design of experiments (DoE) approach to identify the influencing parameters that determine poly-D,L-lactic acid (PDLLA) electrospun scaffold morphologies
【2h】

A design of experiments (DoE) approach to identify the influencing parameters that determine poly-D,L-lactic acid (PDLLA) electrospun scaffold morphologies

机译:实验设计(DoE)方法来确定决定聚D,L-乳酸(PDLLA)电纺支架形态的影响参数

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务,本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文,但由于OA文献来源多样且变更频繁,仍可能出现获取不到、文献不完整或与标题不符等情况,如果获取不到我们将提供退款服务。请知悉。

摘要

Electrospun fibrous materials have increasing applications in regenerative medicine due to the similarity of fibre constructs to the morphology of certain extracellular matrices. Although experimentally the electrospinning method is relatively simple, at the theoretical level the interactions between process parameters and their influence on the fibre morphology is not yet fully understood. Here, we hypothesised that a design of experiments (DoE) model could determine combinations of process parameters that result in significant effects on poly-D,L-lactic acid (PDLLA) fibre morphology. The process parameters used in this study were applied voltage, needle-to-collector distance, flow rate and polymer concentration. Data obtained for mean fibre diameter, standard deviation of the fibre diameter (stdev, measure of fibre morphology) and presence of 'beading' on the fibres (beads per µm2) were evaluated as a measure of PDLLA fibre morphology. Uniform fibres occurred at standard deviations of ≤ 500 nm, 'beads-on-string' morphologies were apparent between ± 500-1300 nm and large beads were observed at ± 1300-1800 nm respectively. Mean fibre diameter was significantly influenced by the applied voltage and interaction between flow rate and polymer concentration. Fibre morphology was mainly influenced by the polymer concentration, while bead distribution was significantly influenced by the polymer concentration as well as the flow rate. The resultant DoE model regression equations were tested and considered suitable for the prediction of parameters combinations needed for desired PDLLA fibre diameter and additionally provided information regarding the expected fibre morphology.
机译:由于纤维构造与某些细胞外基质的形态相似,电纺纤维材料在再生医学中的应用越来越广泛。尽管从实验上讲电纺方法相对简单,但在理论水平上,工艺参数之间的相互作用及其对纤维形态的影响尚不完全清楚。在这里,我们假设实验设计(DoE)模型可以确定对聚D,L-乳酸(PDLLA)纤维形态产生重大影响的工艺参数组合。在这项研究中使用的工艺参数是施加的电压,针到收集器的距离,流速和聚合物浓度。评估获得的平均纤维直径,纤维直径的标准偏差(stdev,纤维形态的度量)和纤维上“珠子”的存在(每μm2珠子)的数据,作为PDLLA纤维形态的度量。均匀纤维的标准偏差为≤500 nm,在±500-1300 nm之间可见“串珠”形态,在±1300-1800 nm处分别观察到大珠。平均纤维直径受到施加电压以及流速和聚合物浓度之间相互作用的显着影响。纤维形态主要受聚合物浓度影响,而珠粒分布受聚合物浓度以及流速显着影响。测试了所得的DoE模型回归方程,并认为该方程适合预测所需PDLLA纤维直径所需的参数组合,并另外提供了有关预期纤维形态的信息。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号