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What factors explain the association between socioeconomic deprivation and reduced likelihood of live-donor kidney transplantation?:A questionnaire based pilot case-control study

机译:哪些因素可以解释社会经济剥夺与活体肾脏移植可能性降低之间的关系?:基于调查表的案例对照研究

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摘要

ObjectivesSocioeconomically deprived individuals with renal disease are less likely to receive a live-donor kidney transplant than less deprived individuals. This study aimed to develop and pilot a questionnaire designed to determine what factors explain this association.DesignQuestionnaire development and a pilot case-control study. Primary aims were to develop and evaluate a questionnaire, assess response rates and to generate data to inform full-scale study design.SettingA UK tertiary renal referral hospital and transplant centre. Participants Invited participants comprised 30 live-donor kidney transplant recipients (cases) and 30 deceased donor kidney transplant recipients (controls). Participants were randomly sampled from all adults who had been transplanted at Southmead Hospital, North Bristol NHS Trust between 1/8/2007 and 31/7/13.MethodsParticipants were posted questionnaires accompanied by an invitation letter from the renal consultant responsible for their care, and a patient information leaflet. Non-responders were sent a second questionnaire after 4-6 weeks. Data was extracted from returned questionnaires and entered onto a REDCapTM database.Results63% (n=38) of those invited returned questionnaires. 16 (42%) declined to answer the question on income. 58% of participants had not asked any of their potential donors to consider living kidney donation (52% LDKT vs 65% DDKT, p=0.44). There was some evidence of a difference between the R3K-T knowledge score for recipients of LDKTs (Mean 6.7, SD 1.8) and for recipients of DDKTs (Mean 4.9, SD 2.1), p=0.008. Variable distribution for the exposure variables of interest were determined.ConclusionsFindings from this study will inform a sample size calculation for a full-scale study. The findings of the full-scale case-control study will help us better understand how socioeconomic deprivation is related to the type of transplant an individual receives. This understanding will help us to design and appropriately tailor an intervention to reduce inequitable access to live-donor kidneytransplantation.
机译:目的与社会经济匮乏的肾脏疾病患者相比,社会经济匮乏的肾脏疾病患者比活体较少的人群接受肾脏活体移植的可能性更低。本研究旨在开发和试行旨在确定哪些因素解释这种关联的问卷。DesignQuestionnaire开发和试点病例对照研究。主要目的是开发和评估调查表,评估回应率并生成数据以为全面研究设计提供依据。设置英国三级肾脏转诊医院和移植中心。参与者受邀参与者包括30位活体供体肾移植受者(病例)和30位已故的供体肾移植受者(对照)。参与者从2007年1月8日至31/7/13在北布里斯托尔NHS Trust的Southmead医院接受移植的所有成年人中随机抽取方法。向参与者发布问卷,并附有负责其护理的肾脏顾问的邀请信,和患者信息单张。 4-6周后向未回答的人发送第二份问卷。从返回的调查表中提取数据并将其输入REDCapTM数据库中。结果邀请的返回调查表中有63%(n = 38)。 16(42%)拒绝回答有关收入的问题。 58%的参与者没有要求任何潜在的捐赠者考虑活体肾脏捐赠(52%LDKT与65%DDKT,p = 0.44)。有证据表明,LDKT接受者的R3K-T知识得分(平均值6.7,SD 1.8)和DDKT接受者的R3K-T知识评分(平均值4.9,SD 2.1)存在差异,p = 0.008。确定了感兴趣的暴露变量的变量分布。结论本研究的发现将为全面研究提供样本量计算的依据。全面病例对照研究的结果将帮助我们更好地了解社会经济剥夺与个人接受的移植类型之间的关系。这种理解将帮助我们设计和适当地制定一项干预措施,以减少获得活体肾脏移植的不平等机会。

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