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Biomarker responses and reproductive toxicity of the effluent from a Chinese large sewage treatment plant in Japanese medaka (Oryzias latipes)

机译:日本medaka(Oryzias latipes)一家中国大型污水处理厂的废水的生物标志物响应和生殖毒性

摘要

The present study was conducted to assess the potential toxicity of the effluent from a large sewage treatment plant (GBD-STP) in Beijing. Japanese medakas (Oryzias latipes) at reproduction active period were exposed to a serial of graded concentrations of the effluent or 100 ng l(-1) of 17-alpha-ethinylestradiol (EE2, positive control). Growth, gonadosomatic index (GSI), hepatosomatic index (HSI), reproductive success, induction potency of vitellogenin (VTG) in male fish and that of 7-ethoxyresorufin-o-deethylase activity (EROD) in male fish liver were used as test endpoints. The growth suppression of fish was observed in a dose-dependent manner, resulting in significant differences in both body length and body weight of medaka above 5% effluent. This effluent can inhibit the growth of gonad of medakas and are more sensitive to male than to female. At exposure concentration of 40% and higher, there was an unexpected decrease of HSI values, which may be resulted from sub-lethal toxicity of effluent to fish liver. VTG of plasma in males were induced in all exposure concentration levels, but not in a dose-dependent manner. The concentration of 5% effluent would be the lowest observed adverse effect level (LOAEL) affecting reproductive success when examining fertile individuals, fecundity and fertilization rate. The overt CYP1A response and higher reproductive toxicity may be indicative of low process efficiency of this STP. (c) 2004 Elsevier Ltd. All rights reserved.
机译:本研究旨在评估北京某大型污水处理厂(GBD-STP)出水的潜在毒性。在繁殖活跃期的日本(Oryzias latipes)暴露于一系列分级浓度的出水或100 ng l(-1)的17-α-乙炔雌二醇(EE2,阳性对照)。试验以雄鱼的生长,性腺体指数(GSI),肝体指数(HSI),繁殖成功,卵黄蛋白原(VTG)的诱导能力以及雄鱼肝中的7-乙氧基-异戊二烯-o-脱乙基酶活性(EROD)的诱导力为测试终点。 。以剂量依赖性的方式观察到鱼的生长受到抑制,导致出水量高于5%的青aka的体长和体重都有显着差异。这种流出物可以抑制青aka的性腺生长,并且对雄性比对雌性更敏感。当暴露浓度为40%或更高时,HSI值会意外降低,这可能是由于废水对鱼肝的亚致死毒性所致。在所有暴露浓度水平下均诱导了男性血浆中的VTG,但并非以剂量依赖性方式引起。当检查可育个体,繁殖力和受精率时,浓度为5%的废水将是影响生殖成功的最低观察到的不良反应水平(LOAEL)。明显的CYP1A反应和较高的生殖毒性可能表明该STP的加工效率低。 (c)2004 Elsevier Ltd.保留所有权利。

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