A Study on Experimental Testicular Disorder II. Recovery from Testicular Dysfunction Produced by Experimental Internal Irradiation of 32P with Special Reference to Histopathological Study on Spermatopoietic Function of the Testicle

摘要

1) Mice weighing between 100 and 200 grams were emplo y ed for this study. Histopapathological study on spermatopoietic function of seminiferous tubule of the testicle removed surgically from I-Group receiving internal irradiation of 32P in a dosis of 250 pc, II-Group with 300 p c, III-Group with 350 pc, IV-Group with 400 pc, and V-Group with 450 p c, 2) Various repairing drugs were administered subcutaneously starting from 24 hour aft e r the irradiation to each group every other day for 3-4 weeks and then recovery of spermatopoietic function was classified histopathologically. 3) A week after internal irradia t ion of 32Pi n a dosis of 250 pc to I-Group, disarrangement, diminution and disappearance of seminiferous tubular epithelium, apperance of giant cells, and slight disturbance of spermatopoietic function were observed. Gonagen forte, Havita, and ATP appeared to improve spermatopoietic function. Synahorin and Mercazole seemed to be less effective than the above substances. 4) Three weeks after internal irradiatio n of 32Pi n a dosis of 300 pc to II-Group, slight changes in seminiferous tubule were spermatozoon disappeared was observed. Marked improvement of spermatopoietic function was observed by administration of Anteron, Luteogen, and Chondron every other day and the less marked improvement was obtained by Royal Jelly. 5) Th r ee weeks after internal irradiation of 82P in a dosis of 350 pc to III-Group, the changes were rather slight but affected site was wider than that in II-Group. The method of administration of was the same as II-Group. The most remarkable improvement of spermatopoietic function was obtained by Parotin, Atropin, yolk, and Nicodermin and Syncorta, Tioctan, Fatogen, and Zyscal produced less marked improvement. 6) Three weekes after internal irradiation of 82P in a do s i s of 400 pc to IV-Group, the changes were slight and regeneration of seminiferous tubule was observed. The marked improvement was obtained by Synahorin, Enarmon, and Orotonsan. PVL and Gonagen forte less markedly improved the function. 7) Two weeks after internal irradiation of 82P in a dosis of 450 pc to V-Group, duct lumen was filled with spermatozoid and there were only few spermatozoon. Spermiocyte was in karyokinesis and giant cells appeared in few duct lumen. Moriamin-S resulted in remarkable improvement of spermatopoietic function. 8) Three weeks after internal irradiation of 32P in a dosis of 600 tic, all phases from disturbance to regeneration were found in seminiferous tubule. 9) In conclusion Parotin, yolk, Atropin, Moriamin-S , Anteron, Luteogen, Orotonsan, and Chondron improved of spermatopoietic function markedly.