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Theory of force-extension curves for modular proteins and DNA hairpins

机译:模块化蛋白质和DNA发夹的力-延伸曲线理论

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摘要

We study a model describing the force-extension curves of modular proteins, nucleic acids, and other biomolecules made out of several single units or modules. At a mesoscopic level of description, the configuration of the system is given by the elongations of each of the units. The system free energy includes a double-well potential for each unit and an elastic nearest-neighbor interaction between them. Minimizing the free energy yields the system equilibrium properties whereas its dynamics is given by (overdamped) Langevin equations for the elongations, in which friction and noise amplitude are related by the fluctuation-dissipation theorem. Our results, both for the equilibrium and the dynamical situations, include analytical and numerical descriptions of the system force-extension curves under force or length control and agree very well with actual experiments in biomolecules. Our conclusions also apply to other physical systems comprising a number of metastable units, such as storage systems or semiconductor superlattices.
机译:我们研究了一个模型,该模型描述了由几个单一单元或模块组成的模块化蛋白质,核酸和其他生物分子的力-延伸曲线。在介观的描述水平上,系统的配置由每个单元的伸长率给出。系统自由能包括每个单元的双阱势以及它们之间的弹性最近邻相互作用。最小化自由能产生系统平衡特性,而其动力学由伸长的(过阻尼)Langevin方程给出,其中摩擦和噪声振幅与波动耗散定理相关。我们在平衡和动力学情况下的结果都包括在力或长度控制下系统力-延伸曲线的分析和数值描述,并且与生物分子的实际实验非常吻合。我们的结论也适用于包含许多亚稳态单元的其他物理系统,例如存储系统或半导体超晶格。

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