In the scope of this thesis functional polymeric nanoparticles were synthesized. The polymer system was limited to the use of poly (2-oxazoline)s as they have proven to be non-toxic and biocompatible and are suitable for the use as polymer therapeutics. In addition, they offer a special advantage over the most frequently used systems in terms of their systematic composition to defined sizes and structures.Different polar monomers were used in a “bottom-up” approach to build up amphiphilic blockcopolymers, which aggregate to core-shell-particles in a selective solvent. These particles were first examined in more detail with respect to their aggregation behavior as a function of their structure.Additional functional groups were placed into the polymeric scaffold by use of targeted functionalization of the monomer system as well as a polymer analogous reaction. Upon micelle formation in aqueous media, UV-initiated radical polymerization was used to form core-crosslinked, stabilized nanoparticles. The dimensions and stability of the core-crosslinked nanoparticles are characterized by dynamic light scattering and fluorescence spectroscopy. A further functional group on the particle surface was used to couple UV active compounds and especially biomedically relevant molecules, such as fluorescent dyes, peptides, and receptor molecules.Additionally the binding of gold nanoparticles was tested to build multifunctional nanoparticles of therapeutic and diagnostic interests.Following initial studies were carried out for drug incorporation and release with the test drug Indomethacin.In a new approach, the coupling of polymeric nanoparticles was tested to influence the size, structure and functionalization of the particles. For this purpose, two different strategies were used. The coupling of complementary functionalities on the particle surface and the use of a bifunctional linker was examined.
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