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In vivo performance of antibiotic embedded electrospun PCL membranes for prevention of abdominal adhesions

机译:抗生素嵌入的电纺PCL膜在预防腹部粘连中的体内表现

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摘要

The aim of this study was to prepare nonwoven materials from poly(-caprolactone) (PCL) and their antibiotic containing forms by electrospinning, so as to prevent postsurgery induced abdominal adhesions in rats. -Caprolactone was first polymerized by ring-opening polymerization, and then it was processed into matrices composed of nanofibers by electrospinning. A model antibiotic (Biteral®) was embedded within a group of PCL membranes. In the rat model, defects on the abdominal walls in the peritoneum were made to induce adhesion. The plain or antibiotic embedded PCL membranes were implanted on the right side of the abdominal wall. No membrane implantation was made on the left side of the abdominal wall that served as control. Macroscopical and histological evaluations showed that using these barriers reduces the extent, type, and tenacity of adhesion. The antibiotic embedded membranes significantly eliminated postsurgery abdominal adhesions, and also improved healing.
机译:这项研究的目的是通过电纺丝从聚己内酯(PCL)及其含抗生素的形式制备非织造材料,以防止术后引起的大鼠腹部粘连。 -己内酯首先通过开环聚合进行聚合,然后通过电纺丝将其加工成由纳米纤维组成的基质。将模型抗生素(Biteral®)嵌入一组PCL膜中。在大鼠模型中,腹膜腹壁上的缺陷可引起粘连。将普通的或抗生素嵌入的PCL膜植入腹壁的右侧。在作为对照的腹壁左侧未进行膜植入。宏观和组织学评估表明,使用这些屏障会降低粘附的程度,类型和强度。嵌入抗生素的膜可显着消除手术后腹部的粘连,并改善愈合。

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