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Sustained drug release from multi-layered sequentially crosslinked electrospun gelatin nanofiber mesh

机译:从多层顺序交联的电纺明胶纳米纤维网中持续释放药物

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摘要

The aim of this study is to develop electrospun gelatin nanofibers based drug delivery carrier to achieve controlled and sustainable release of hydrophobic drug (piperine) for prolonged time. To accomplish this, we devised some strategies such as sandwiching the drug loaded gelatin nanofiber mesh with another gelatin nanofiber matrix without drug (acting as diffusion barrier), sequential crosslinking and finally, a combination of both. As fabricated multilayered electrospun nanofibers mesh was first characterized in terms of degradation study, morphology, drug-polymer interactions, thermal stability followed by studying their release kinetics in different physiological pH as per the gastrointestinal tract. Our results show that with optimized diffusional barrier support and sequential crosslinking together, a zero order sustained drug release up to 48 h may be achieved with a flexibility to vary the drug loading as per the therapeutic requirements. This work lays out the possibility of systematic design of multilayer nano-fiber mesh of a biopolymer as a drug delivery vehicle for hydrophobic drugs with a desired signature of zero order release for prolonged duration.
机译:这项研究的目的是开发基于静电纺丝明胶纳米纤维的药物输送载体,以实现疏水性药物(胡椒碱)的可控和可持续释放,延长时间。为此,我们设计了一些策略,例如将载有药物的明胶纳米纤维网与另一种没有药物的明胶纳米纤维基质(用作扩散屏障)夹在中间,依次进行交联,最后将两者结合。当制造多层电纺纳米纤维网时,首先要根据降解研究,形态,药物-聚合物相互作用,热稳定性进行表征,然后研究其在不同生理pH下的胃肠道释放动力学。我们的结果表明,通过优化的扩散屏障支持和顺序交联在一起,可以实现长达48小时的零级持续药物释放,并且可以根据治疗要求灵活地改变载药量。这项工作提出了系统设计生物聚合物多层纳米纤维网作为疏水药物的药物输送载体的系统设计的可能性,该疏水性药物具有所需的零级释放特征,可延长使用时间。

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