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Soy Lecithin but Not Egg Lecithin Decreased the Plasma Cholesterol Concentration in Golden Syrian Hamsters

机译:大豆卵磷脂而不是鸡蛋卵磷脂降低了金色叙利亚仓鼠的血浆胆固醇浓度

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摘要

Egg lecithin differs from soy lecithin in its phospholipid profile and fatty acid composition. The current study was designed to test whether egg lecithin or soy lecithin decreased the plasma cholesterol concentration in hamsters that are used as a model for humans. Male golden Syrian hamsters were assigned randomly to eight dietary treatments lasting 4 weeks (n=10 per treatment) that contained 0.12% (wt/wt) of cholesterol and varied amount of supplemental lipids. The diet groups were: control with no supplemental lipid, 0.05%, 0.5%, and 5% (wt/wt) of egg lecithin or soy lecithin, respectively, and 5% (wt/wt) of soybean oil. Dietary soy lecithin decreased the plasma cholesterol concentration compared with control in a dosage- and time-dependent manner. The 5% soy lecithin treatment greatly decreased the final plasma total cholesterol and LDL-cholesterol compared with the control (p\u3c0.0001). In addition, the 5% soy lecithin supplementation caused greater decrease in plasma total cholesterol than did the 5% soybean oil treatment (p\u3c0.05), indicating effects beyond the fatty acid composition. The cholesterol absorption measured on day 24, however, was lower in the control group compared with all other treatments (p\u3c0.05). Overall, dietary soy lecithin but not egg lecithin decreased the plasma cholesterol concentration in hamsters via a mechanism other than decreasing cholesterol absorption.
机译:卵磷脂与大豆卵磷脂的磷脂谱和脂肪酸组成不同。当前的研究旨在测试鸡蛋卵磷脂或大豆卵磷脂是否会降低用作人类模型的仓鼠的血浆胆固醇浓度。将雄性叙利亚金黄仓鼠随机分配到八种饮食治疗中,这些饮食持续4周(每次处理n = 10),其中包含0.12%(wt / wt)的胆固醇和不同量的补充脂质。饮食组为:无补充脂质的对照组,分别为0.05%,0.5%和5%(wt / wt)的卵磷脂或大豆卵磷脂和5%(wt / wt)的大豆油。与对照相比,膳食大豆卵磷脂以剂量和时间依赖性方式降低血浆胆固醇浓度。与对照相比,5%大豆卵磷脂处理可显着降低最终血浆总胆固醇和LDL-胆固醇(p \ u3c0.0001)。另外,与5%大豆油处理相比,补充5%大豆卵磷脂引起的血浆总胆固醇降低更大(p \ u3c0.05),表明其作用超出了脂肪酸组成。然而,与所有其他治疗相比,对照组在第24天测得的胆固醇吸收更低(p \ u3c0.05)。总体而言,日粮大豆卵磷脂而非鸡蛋卵磷脂通过降低胆固醇吸收的其他机制降低了仓鼠血浆胆固醇的浓度。

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