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Recruitment and retention strategies and the examination of attrition bias in a randomised controlled trial in children’s centres serving families in disadvantaged areas of England

机译:在为英格兰贫困地区的家庭服务的儿童中心进行的一项随机对照试验中,研究人员的招募和保留策略以及减员偏差的检查

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摘要

Background: Failure to retain participants in randomised controlled trials and longitudinal studies can cause significant methodological problems. We report the recruitment and retention strategies of a randomised controlled trial to promote fire-related injury prevention in families with pre-school children attending children’s centres in disadvantaged areas in England.ududMethods: Thirty-six children’s centres were cluster randomised into one of three arms of a 12-month fire related injury prevention trial. Two arms delivered safety interventions and there was one control arm. Retention rates compared the numbers of participants responding to the 12-month questionnaire to the number recruited to the trial. Multivariable random effects logistic regression was used to explore factors independently associated with participant retention.ududResults: The trial exceeded its required sample size through the use of multiple recruitment strategies. All children’s centres remained in the study, despite increased reorganisation. Parent retention was 68% at 12 months, ranging from 65% to 70% across trial arms and from 62% to 74% across trial sites. There was no significant difference in the rates of retention between trial arms (p = 0.58) or between trial sites (p = 0.16). Retention was significantly lower amongst mothers aged 16–25 years than older mothers [adjusted odds ratio (AOR) 0.57, 95% CI 0.41, 0.78], those living in non-owner occupied accommodation than in owner occupied accommodation (AOR 0.53, 95% CI 0.38, 0.73) and those living in more disadvantaged areas (most versus least disadvantaged quintiles AOR 0.50, 95% CI 0.30, 0.82).ududConclusions: Studies recruiting disadvantaged populations should measure and report attrition by socioeconomic factors to enable determination of the extent of attrition bias and estimation of its potential impact on findings. Where differential attrition is anticipated, consideration should be given to over-sampling during recruitment and targeted and more intensive strategies of participant retention in these sub-groups. In transient populations collection of multiple sources of contact information at recruitment and throughout the study may aid retention.ududTrial registration: Clinicaltrials.gov identifier: NCT01452191; Date of registration: 10 October 2011, ISRCTN65067450.
机译:背景:未能保留随机对照试验和纵向研究的参与者可能会导致重大的方法学问题。我们报告了一项随机对照试验的招募和保留策略,以促进英格兰弱势地区有学龄前儿童就读儿童中心的家庭预防火灾相关伤害。 ud udMethods:将36个儿童中心聚类为一个一项为期12个月的与火相关的伤害预防试验的三支武器。有两个部门提供了安全干预措施,还有一个控制部门。保留率将回答12个月问卷的参与者人数与该试验的人数进行比较。结果:该试验通过使用多种招募策略超出了其所需的样本量。尽管重组增加,所有儿童中心仍保留在研究中。在12个月时,父母保留率是68%,在试验组中为65%至70%,在试验场所中为62%至74%。试验组之间(p = 0.58)或试验部位之间(p = 0.16)的保留率无显着差异。在16-25岁年龄段的母亲中,保留率显着低于年龄较大的母亲[调整后的优势比(AOR)0.57,95%CI 0.41,0.78],那些居住在非所有者住所中的母亲要比所有者住所(AOR 0.53,95%) CI 0.38,0.73)和那些处境更不利地区的人(最不利的五分之一人口与最弱的五分位数AOR 0.50,95%CI 0.30,0.82)。损耗偏倚的程度及其对发现的潜在影响的估计。如果预计会有不同程度的人员流失,则应考虑在招募期间进行过度抽样,以及在这些亚组中有针对性和更深入地保留参与者的策略。在流动人口中,在招募时和整个研究期间收集多种联系信息来源可能有助于保留。 ud ud试验注册:Clinicaltrials.gov标识符:NCT01452191;注册日期:2011年10月10日,ISRCTN65067450。

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