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Determinants of Nocturnal Cardiovascular Variability and Heart Rate Arousal Response in Restless Legs Syndrome (RLS)/Periodic Limb Movements (PLMS)

机译:躁动腿综合征(RLS)/周期性肢体运动中夜间心血管变异性和心率唤醒反应的决定因素/周期性肢体运动(PLMS)

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摘要

Recent studies have suggested that restless legs syndrome is associated with an increased prevalence of cardiovascular diseases mediated by sympathetic activation occurring during periodic limb movements. The aim of this study was to establish which factors affect the degree of sympathetic activation during the basal condition and during periodic limb movements that may contribute to increased vascular risk. Fifty untreated restless legs syndrome patients aged 62.6 ± 11.1 y, free of cardiovascular diseases, were examined. Heart rate variability was calculated during wakefulness and all sleep stages, during periods with and without periodic limb movements. Heart rate changes before and after periodic limb movement onset were analyzed to assess the arousal response to periodic limb movements. Both analyses took into account the effects of age, gender, periodic limb movement duration, periodic limb movement index, periodic limb movement interval and periodicity, and magnitude of muscular activity (electromyogram power). Compared to periods without periodic limb movements, a significant increase in sympathetic activity occurred in periods with periodic limb movements, independent of age, sex and periodic limb movement characteristics. Data obtained from the cardiac arousal response to periodic limb movements showed that electromyogram power is the factor affecting sympathetic tonus. These results suggest that other factors, such as electromyogram power and individual susceptibility, should be considered in the assessment of the vascular risk related to restless legs syndrome.
机译:最近的研究表明,焦躁的腿综合征与在周期性肢体运动中发生的交感神经激活介导的心血管疾病的普遍性增加有关。本研究的目的是建立哪些因素影响基础条件期间的交感神经程度,并且在可能导致血管风险增加的周期性肢体运动中。检查了五十个未经处理的焦点患者62.6±11.1 y,没有心血管疾病。在醒来的时间内,在随着周期性肢体运动期间计算心率变异性和所有睡眠阶段。分析了周期性肢体运动开始前后的心率变化,评估了对周期性肢体运动的唤醒反应。两者分析都考虑了年龄,性别,周期性肢体运动持续时间,周期性肢体运动指数,周期性肢体运动间隔和周期性的效果,以及肌肉活动的幅度(肌电图力)。与没有周期性肢体运动的时期相比,在具有周期性肢体运动的时期发生的交感神经活动的显着增加,与年龄,性别和周期性的肢体运动特性无关。从心脏唤起对周期性肢体运动获得的数据表明,电灰度力是影响交感神经的因素。这些结果表明,在评估与焦躁的腿综合征相关的血管风险的评估中,应考虑其他因素,例如电灰度动力和个人敏感性。

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