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A Purification Strategy Utilizing Hydrophobic Interaction Chromatography to Obtain Homogeneous Species from a Site-Specific Antibody Drug Conjugate Produced by AJICAP™ First Generation

机译：利用疏水相互作用色谱法从AJICAP™第一代产生的位点特异性抗体药物缀合物中获得均匀物种的纯化策略

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Yutaka Matsuda; Monica Leung; Tatsuya Okuzumi; Brian Mendelsohn;
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年度 2020
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1. Comparison of Analytical Methods for Antibody-Drug Conjugates Produced by Chemical Site-Specific Conjugation: First-Generation AJICAP [J] . Matsuda Yutaka, Robles Veronica, Malinao Maria-Christina, Analytical chemistry . 2019,第20期

机译：化学位点特异性缀合产生的抗体 - 药物缀合物分析方法的比较：第一代AJICAP
2. Good Manufacturing Practice Strategy for Antibody–Drug Conjugate Synthesis Using Site-Specific Chemical Conjugation: First-Generation AJICAP [J] . Yutaka Matsuda, Colin Clancy, Zhala Tawfiq, ACS Omega . 2019,第24期

机译：使用位点特异性化学偶联合成抗体-药物偶联物的良好生产规范策略：第一代AJICAP
3. Analysis of antibody-drug conjugates by comprehensive on-line two-dimensional hydrophobic interaction chromatography x reversed phase liquid chromatography hyphenated to high resolution mass spectrometry. II- Identification of sub-units for the characterization of even and odd load drug species [J] . Sarrut Morgan, Fekete Szabolcs, Janin-Bussat Marie-Claire, Journal of chromatography, B. Analytical technologies in the biomedical and life sciences . 2016,第Null期

机译：通过高分辨率的质谱联用的综合在线二维疏水相互作用色谱x反相液相色谱分析抗体-药物偶联物。 II-鉴定用于偶数和奇数负载药物种类表征的亚单位
4. Using Hydrophilic Interaction Chromatography - Mass Spectrometry for Heightened Product Characterization to Overcome Challenges with Hydrophobic Antibody Drug Conjugates and Monoclonal Antibodies [C] . Jacquelynn Smith, Matthew A. Lauber, Stephan M. Koza, ASMS Conference on Mass Spectrometry and Allied Topics . 2016

机译：使用亲水性相互作用色谱 - 质谱法加热的产品特征，以克服疏水性抗体药物缀合物和单克隆抗体的挑战
5. Modeling of protein monomer/aggregate purification by hydrophobic interaction chromatography: Application to column design and process optimization. [D] . Kamga, Mark-Henry Mbahmi. 2011

机译：疏水相互作用色谱法对蛋白质单体/聚集体纯化的建模：在色谱柱设计和工艺优化中的应用。
6. A Purification Strategy Utilizing Hydrophobic Interaction Chromatography to Obtain Homogeneous Species from a Site-Specific Antibody Drug Conjugate Produced by AJICAP™ First Generation [O] . Yutaka Matsuda, Monica Leung, Tatsuya Okuzumi, 2020

机译：利用疏水相互作用色谱法从AJICAP™第一代产生的位点特异性抗体药物缀合物中获得均匀物种的纯化策略
7. Universal Affinity Capture Liquid Chromatography-Mass Spectrometry Assay for Evaluation of Biotransformation of Site-Specific Antibody Drug Conjugates in Preclinical Studies [O] . -1

机译：通用亲和捕获液相色谱 - 质谱法测定用于评价临床前研究的位点特异性抗体药物缀合物的生物转化

A Purification Strategy Utilizing Hydrophobic Interaction Chromatography to Obtain Homogeneous Species from a Site-Specific Antibody Drug Conjugate Produced by AJICAP™ First Generation

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