ntroduction: Preventive resin restorations (PRR) are the conservative choice for the most common cariouslesions in children. Thus, new age flowable resin composites with higher filler content are readily used. The aimof this study was to evaluate the microshear bond strength and microleakage of two flowable resin compositescontaining different percentages of nano zinc oxide (NZnO) particles, which have proven to have antimicrobialproperties.Methods: This experimental in-vitro study was carried out in the Dental Material Research Center of BabolUniversity of Medical Sciences in 2015. One nanohybrid and one nanofill flowable resin composite were chosenand modified with the incorporation of 1% and 3% Wt NZnO particles. Six groups (n=10, 0%, 1%, and 3%) ofresin composite sticks on dental enamel (2×2mm) were prepared to be placed in the microtensile tester. Themicroshear bond strength magnitude (MPa) was recorded at the point of failure. A class I box (3×0.8×1 mm) wasprepared on 60 premolars and filled using the resin composites (6 groups, n=10). The specimens were immersedin a 5% basic fuschin solution and sectioned bucco-lingually to view the microleakage using a stereomicroscope.One-way ANOVA and Tukey tests for microshear and Wilcoxon and Kruskal–Wallis tests for microleakage wereused to analyze the data in the IBM SPSS Statistics version 22 software.Results: The bond strength of the 3% clearfill group significantly decreased while no significant change occurredin the bond strength in other groups. The Z-350 group had significantly lower microleakage as nanoparticlesincreased. No significant difference was observed in the clearfill group.Conclusion: Up to 3% Wt incorporation of NZnO particles will not diversely alter the bond strength, but it willbe beneficial in providing antimicrobial effects with lower microleakage rates
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