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The relationship of bone properties using high resolution peripheral quantitative computed tomography to radiographic components of hip osteoarthritis

机译:使用高分辨率外周定量计算断层扫描与髋关节骨关节炎的射线分量的骨骼性质的关系

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摘要

Objective: Positive associations between radiographic osteoarthritis (OA) and areal bone mineral density (BMD) have been demonstrated and appear strongest when bony features of OA are considered. To date, these associations have not been assessed using HRpQCT.Design: A total of 318 participants (170 men and 148 women), aged 72.1–81.4 years from a non-selected cohort, underwent HRpQCT of the distal radius and tibia along with hip radiography. Differences in bone microarchitecture were assessed between those with and without osteophytes, sclerosis or joint space narrowing (JSN) in either hip.Results: Men with osteophytes alone had significantly higher radial trabecular volumetric BMD (Tb.vBMD) and radial and tibial trabecular thickness (Tb.Th). Men with both sclerosis and osteophytes had significantly higher cortical volumetric BMD (Ct.vBMD) and cortical thickness (Ct.Th) at the distal tibia than those with osteophytes alone (P 0.05). These relationships were maintained after adjustment for age and Body Mass Index (BMI), and were not replicated in women. Bone microarchitecture did not differ significantly in those with JSN from those without it in men or women.ConclusionsOur findings suggest higher Tb.vBMD and Tb.Th in men with osteophytosis but higher tibial Ct.vBMD and Ct.Th in men with hip joint sclerosis. These results do however require replication in other cohorts.
机译:目的:在考虑OA的骨骼特征时,已经证明了射线照相骨关节炎(OA)和面积骨密度(BMD)之间的阳性关联。迄今为止,尚未使用HRPQCT.Design评估这些协会:共有318名参与者(170名男性和148名妇女),从未选定的队列,远端半径和胫骨的HRPQCT和HIP一起进行了72.1-81.4岁射线照相。在HIP.Results中,在具有和没有骨赘的那些中评估骨微架构的差异,骨折,硬化或联合空间缩小(JSN):单独具有骨赘的男性具有显着高的径向小梁体积BMD(TB.VBMD)和径向和胫骨小梁厚度( tb.th)。患有硬化症和骨赘的男性在远端胫骨上具有显着更高的皮质体积BMD(CT.VBMD)和皮质厚度(CT.TH),而不是单独具有骨折的胫骨(P <0.05)。这些关系在调整年龄和体重指数(BMI)后维持,并且在女性中没有复制。骨微架构在男性或女性中,在没有它的人中没有显着差异.Clusionsour调查结果表明,在具有骨折的男性中,患有骨折的男性和Tb.th。具有髋关节硬化的男性患者高等的胫骨CT.VBMD和CT.TH 。然而,这些结果确实需要在其他队列中复制。

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