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Stem Cell Based Tissue Engineering and Regenerative Medicine: A Review Focusing on Adult Stem Cells

机译:基于干细胞的组织工程和再生医学:以成人干细胞为重点的综述

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摘要

Tissue engineering has emerged as a field that attempts to harness the bodiesu27 own developmental and repair features to treat diseases and illnesses. Many of these illnesses are caused by necrosis or loss of functionality of complete organs or specific cell types. Early discoveries in embryonic stem cells fueled a wave of research that led to claims about possibly regenerating nonfunctioning organs. Although we are still far away from being able to grow functional organs in a Petri dish, the field continues to progress forward, and new clinical trials have been approved for using both embryonic and adult stem cell based solutions for regenerative medicine and tissue engineering. Current trends have moved towards adult stem cells for cell based therapies as they offer an autologous source and are less tumorigenic than their embryonic and induced-pluripotent stem cell counter parts. This review will begin with an outline of stem cell classes and then focus on current therapies in myocardial tissue repair, neural tissue repair, diabetes, as well as osteogenic and chondrogenic differentiation are also reviewed.
机译:组织工程学已经成为试图利用人体自身的发育和修复特征来治疗疾病的领域。这些疾病中的许多是由坏死或完整器官或特定细胞类型的功能丧失引起的。胚胎干细胞的早期发现推动了一波研究浪潮,导致人们对可能再生无功能器官的说法提出了要求。尽管我们仍然无法在培养皿中生长功能器官,但该领域仍在继续发展,并且已经批准了将基于胚胎和成体干细胞的溶液用于再生医学和组织工程的新的临床试验。当前的趋势已经转向用于基于细胞的治疗的成体干细胞,因为它们提供了自体来源,并且比它们的胚胎干细胞和诱导多能干细胞计数器的致癌性更低。这篇综述将从干细胞类别的概述开始,然后重点介绍心肌组织修复,神经组织修复,糖尿病以及成骨和软骨形成分化方面的当前疗法。

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