首页> 外文OA文献 >Azithromycin in the Treatment of Preterm Prelabor Rupture of Membranes Demonstrates a Lower Risk of Chorioamnionitis and Postpartum Endometritis with an Equivalent Latency Period Compared with Erythromycin Antibiotic Regimens
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Azithromycin in the Treatment of Preterm Prelabor Rupture of Membranes Demonstrates a Lower Risk of Chorioamnionitis and Postpartum Endometritis with an Equivalent Latency Period Compared with Erythromycin Antibiotic Regimens

机译:阿奇霉素在治疗早产预防膜破裂的情况下,与红霉素抗生素治疗方案相比,幼苗炎和产后子宫内膜炎的风险较低

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摘要

Objective. To determine if antibiotic regimens including azithromycin versus erythromycin has an impact on pregnancy latency and development of clinical chorioamnionitis in the context of preterm prelabor rupture of membranes. Study Design. We conducted a prospective observational cohort study and followed all women receiving antibiotic regimens including either azithromycin or erythromycin in the context of preterm prelabor rupture of membranes. Primary outcomes were the duration of pregnancy latency period and development of chorioamnionitis. Secondary outcomes included neonatal sepsis with positive blood culture, cesarean delivery, postpartum endometritis, and meconium-stained amniotic fluid. Results. This study included 310 patients, with 142 receiving the azithromycin regimen and 168 receiving the erythromycin regimen. Patients receiving the azithromycin regimen had a statistically significant advantage in overall rates of clinical chorioamnionitis (13.4% versus 25%, p=0.010), neonatal sepsis (4.9% versus 14.9%, p=0.004), and postpartum endometritis (14.8% versus 31%, p=0.001). In crude and adjusted models, when comparing the azithromycin group with the erythromycin group, a decreased risk was noted for the development of clinical chorioamnionitis, neonatal sepsis, and postpartum endometritis. Pregnancy latency by regimen was not significantly different in crude and adjusted models. Conclusion. Our study suggests that latency antibiotic regimens substituting azithromycin for erythromycin have lower rates and decreased risk of clinical chorioamnionitis, neonatal sepsis, and postpartum endometritis with no difference in pregnancy latency.
机译:客观的。要确定是否抗生素疗法包括阿奇霉素与红霉素有膜的早产prelabor破裂的情况下对怀孕潜伏期和临床绒毛膜羊膜炎的发展产生影响。学习规划。我们进行了一项前瞻性观察队列研究和遵循所有接受抗菌药物治疗方案,包括在膜的早产prelabor破裂的背景下无论是阿奇霉素或红霉素的妇女。主要成果是妊娠的潜伏期和绒毛膜羊膜炎的发展时间。次要终点包括与血培养阳性,剖宫产,产后子宫内膜炎,和胎粪污染羊水新生儿败血症。结果。这项研究包括310例,与142接收阿奇霉素方案和168接收红霉素方案。接收阿奇霉素方案患者具有统计学显著优点在临床绒毛膜羊膜炎(13.4%对25%,p值= 0.010),新生儿败血症(4.9%对14.9%,P = 0.004),和产后子宫内膜炎(14.8%对31的整体速率%,p = 0.001)。在原油和调整的模型,阿奇霉素组,红霉素组比较时,一个风险临床绒毛膜羊膜炎,新生儿败血症和产后子宫内膜炎的发展指出的下降。通过方案怀孕延迟是不是在原油和调整的模型显著不同。结论。我们的研究表明,延迟抗生素疗法阿奇霉素代替红霉素具有较低的利率,降低临床绒毛膜羊膜炎,新生儿败血症的风险,产后妊娠合并潜伏期无差异子宫内膜炎。

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