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Rush-Larsen time-stepping methods of high order for stiff problems in cardiac electrophysiology

机译:高阶刚阶段刚性问题的匆忙 - 电生理学中的时间步进方法

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摘要

To address the issues of stability and accuracy for reaction-diffusionequations, the development of high order and stable time-stepping methods isnecessary. This is particularly true in the context of cardiacelectrophysiology, where reaction-diffusion equations are coupled with stiffODE systems. Many research have been led in that way in the past 15 yearsconcerning implicit-explicit methods and exponential integrators. In 2009,Perego and Veneziani proposed an innovative time-stepping method of order 2. Inthis paper we present the extension of this method to the orders 3 and 4 andintroduce the Rush-Larsen schemes of order k (shortly denoted RL_k). The RL_kschemes are explicit multistep exponential integrators. They display a simplegeneral formulation and an easy implementation. The RL_k schemes are shown tobe stable under perturbation and convergent of order k. Their Dahlquiststability analysis is performed. They have a very large stability domainprovided that the stabilizer associated with the method captures well enoughthe stiff modes of the problem. The RL_k method is numerically studied asapplied to the membrane equation in cardiac electrophysiology. The RL k schemesare shown to be stable under perturbation and convergent oforder k. TheirDahlquist stability analysis is performed. They have a very large stabilitydomain provided that the stabilizer associated with the method captures wellenough the stiff modes of the problem. The RL k method is numerically studiedas applied to the membrane equation in cardiac electrophysiology.
机译:为了解决反应扩散的稳定性和准确性问题,需要高阶和稳定的时间步进方法。这在心脏电磁生理的背景下尤其如此,其中反应扩散方程与臭氧系统耦合。在过去的15年度截然不同的方法和指数集成商中,许多研究已经以这种方式导致了这种方式。 2009年,Perego和Veneziani提出了一种创新的时间步进订单方法2. Inthis Paper我们向订单3和4展示了该方法的延伸,并介绍了Rush-Larsen的顺序k(短表示的RL _K)。 RL _kschemes是明确的多步指数集成商。它们显示出简单的配方和简单的实施。 RL _K方案显示在扰动和订单k的扰动下稳定。他们进行了Dahlquiststability分析。它们具有非常大的稳定性域,使得与该方法相关的稳定剂很好地捕获问题的僵硬模式。 RL _K方法以心脏电生理学中的膜方程数量地研究。 RL K模式显示在扰动和ofter k的扰动和收敛下是稳定的。他们的稳定性分析进行了。它们具有非常大的稳定性域,只要与该方法相关的稳定器捕获了问题的僵硬模式。 RL K方法是在数值上研究的,其应用于心脏电生理学中的膜方程。

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