Initial Submission: Letter from Dow Chemical Co. to USEPA regarding Dermal Teratology Study of 1,3-Dimethyl-2-Imidazolidinone, dated 04/08/1996

摘要

Preliminary, unaudited results from a dermal teratology study (in which the material was administered for 6 hours/day on gestation days 6 to 15 at 0, 10, 100, and 400 mg/kg/day) indicate a statistically significant decrease in gravid uterine weight and fetal body weight at the 400 mg/kg/day dose level. These parameters were not affected at the 100 or 10 mg/kg/day dose groups. Maternal body weights were significantly decreased at 400 mg/kg/day during gestation days 16-21. Body weight gains of the female rats given 400 mg/kg/day were also statistically decreased on days 6-9, 9-12, 12-16, 0-21 and 6-16. At 100 mg/kg/day, body weight gains were statistically lower than the controls during the treatment period (days 6-16) and days 19-21 of gestation. No effects on maternal body weights or body weight gains were observed at 10 mg/kg/day.