Toxicology and Carcinogenesis Studies of 1,2-Dihydro-2, 2,4-Trimethylquinoline(CAS No. 147-47-7) in F344/N Rats and B6C3F1 Mice (Dermal Studies) and the Initiation/Promotion (Dermal Study) in Female SENCAR Mice

摘要

1,2-Dihydro-2, 2,4-trimethylquinoline (monomer) is used as antioxidant instyrene-butadiene and nitrile-butadiene rubbers and latexes. It was nominated by the National Cancer Institute as part of a review of chemicals used in the manufacture and processing of rubber, during whichpotential occupational and consumer exposure to this compound can occur.It was selected for evaluation becasue it is a derivative of quinoline, a known rodent carcinogen, and was regarded as having potential carcinogenic activity. Because of the pattern of use and exposure, dermal administration was considered most appropriate.