NIEHS Technical Report on the Reproductive, Developmental, and General Toxicity211 Study of 3'-Azido-3'-Deoxythymidine (AZT) and Isoniazid Combinations (CAS Nos. 211 30516-87-1 and 54-85-3) Administered by Gavage to Swiss (CD-1 (Trade Name)) Mice

摘要

The toxicity of AZT and isoniazid combination therapy was assessed in Swiss (CD-1211u001e(Trade name)) mice. Gavage doses of AZT (100, 200, or 400 mg/kg) were 211u001eadministered alone or in combination with isoniazid (50, 100, or 150 mg/kg). Male 211u001emice (10 per group) were dosed from day 5 until the day prior to sacrifice on day 211u001e25 or 26. Prior to dosing (days 0 to 4), the male mice were cohabited with a 211u001egroup of female mice (20 per group), hereafter referred to as female-B mice. The 211u001esperm-positive female-B mice were dosed on days 6 through 15 of gestation and 211u001esacrificed on scheduled day 4 of lactation. A second group of female mice (20 per 211u001egroup), hereafter referred to as female-A mice, were dosed from day 0 throughout 211u001emating on days 9 to 13 until sacrifice on day 18 of gestation. Adult mice were 211u001eevaluated for clinical findings, mean body weights, and hematologic parameters. 211u001eOffspring were evaluated for viability, external anomalies, and mean fetal 211u001eweight.