Effects of Controlled Ozone Exposure in Volunteers with Cardiovascular Disease

摘要

The authors hypothesized, on the basis of epidemiologic and animal toxicologicfindings, that exposure to ozone (O3) in air pollution can acutely impair cardiovascular function in susceptible human poulations. We tested this hypothesis in 10 hypertensive and 6 healthy male volunteers aged 40-78 yr. Each subject, after cathereterization of the right heart and a radical artery, was exposed in an environmentally controlled chamber to filtered air (FA) on one day and to 0.3 ppm 03 on the following day, for 3-hr periods with intermittent exercise. Relative to FA, 03 exposure induced little change in cardiac index, pressures and resistances in the central, pulmonary, or peripheral circulations, cardiac enzymes, homeostatic hormones (norepinephrine, epinephrine), or arterial oxygen saturation, as measured at rest after exposure.