In-Vivo Diagnosis of Chemically Induced Melanoma in an Animal Model Using UV-Visible and NIR Elastic-Scattering Spectroscopy: Preliminary Testing

摘要

Elastic light scattering spectroscopy (ESS) has the potential to provide spectrathat contain both morphological and chromophore information from tissue. We report on a preliminary study of this technique, with the hope of developing a method for diagnosis of highly-pigmented skin lesions, commonly associated with skin cancer. Four opossums were treated with dimethylbenz(a)anthracene to induce both malignant melanoma and benign pigmented lesions. Skin lesions were examined in vivo using both UV-visible and near infrared (NIR) ESS, with wavelength ranges