Final Study Report on the Developmental Toxicity Evaluation for Silver Acetate (CAS No. 563-63-3) Administered by Gavage to Sprague-Dawley (CD (Trade Name)) Rats on Getstational Days 6 Through 19

摘要

The EPA Office of Solid Waste and Emergency Response (OSWER) nominated silver for developmental and reproductive toxicity testing, based upon potential exposure to metallic silver and silver compounds that may occur in the workplace, in the environment from releases of silver-containing products and waste streams, and through the chronic intentional ingestion of colloidal silver. Based on the results of a screening study conducted in this laboratory in CD rats, the present study was conducted using female Sprague-Dawley-derived (CD) rats dosed by gavage with silver acetate in 1% aqueous methylcellulose (10, 30, or 100 mg/kg/day) or vehicle on gd 6 through 19. Silver acetate contains 64.6% silver by weight. Therefore the lowest dose (10 mg/kg/day as silver acetate) was equivalent to approximately 6.5 mg silver/kg/day or 1300 times the human reference dose (Rfd) of 5 micrograms/kg/day for argyris, a discoloration of the skin or mucosal surfaces through the deposition of silver in the tissues.