PON1 As a Potential Treatment for Organophosphate Poisoning.

摘要

The paraoxonase enzymes (PON1, PON2, and PON3) play important roles in geneenvironment interactions, drug metabolism, and susceptibility to vascular and infectious disease. Since 2000, SBRP-funded researchers at the University of Washington (http://tools.niehs.nih.gov/sbrp/programs/Program_detail.cfm?Project_ ID=P42ES4696/) (UW) have conducted a series of investigations to determine: 1) the role of PON1 in modulating the toxicity of mixtures of organophosphate (OP) compounds, and 2) the direct impacts of PON1 on individuals’ susceptibility to pesticide poisoning and cardiovascular diseases.