Review of Some Applications of Oak Ridge Centrifuges to the Vaccine Development Program

摘要

Equipment and techniques developed at Oak Ridge National Laboratory have demonstrated their usefulness in virus isolation, and are potentially applicable to large-scale production of vaccine. The preparation of vaccines that contain only virus particles, or viral subunits, was one of the two urgent fractionation problems that stimulated zonal centrifuge development. The other one was the search for trace amounts of virus in pathological samples. Over 40 rotor systems and rotor modifications have been constructed. These are grouped into classes based on speed ranges and uses. (Author)