Feasibility Study: Parainfluenza Virus Isolated Antigen Vaccine

摘要

Efforts are being made toward the goal of preparing an extracted antigen vaccine for animal evaluation and possible clinical test - perhaps by intranasal immunization - this year. The immediate objective is the development of a type 1 vaccine to meet this goal. Efforts to develop a potency test were continued. Fair to good hemagglutinating inhabiting antibody response was obtained in guinea pigs to monovalent fluid virus and virus antigen preparation of all three serotypes. Excellent response was obtained to water-in-oil emulsified vaccines. Initial studies on concentration, extraction, stabilization, UV inactivation and animal immunization were undertaken with the two remaining serotypes. It was found that in most respects the type 2 virus is quite similar to type 1. However, it appears to be a much more effective antibody stimulator. On the basis of very limited information, type 3 seems to differ in several important aspects from the other two types - particularly with respect to its extraction and stability characteristics. Exploratory studies of intranasal immunization and challenge of guinea pigs were begun. (Author)