Intravenous Infusion to Male and Female Dogs - Cytosine Arabinoside Hydrochloride (Ara-C, Cytostine Arabinoside Triacetate (Ara-C Triacetate), and Uracil Arabinoside Hydrochloride (Ara-U)

摘要

An investigation was undertaken to develop information as to the optimum intravenous dose scheduling for cytosine arabinoside hydrochloride (Ara-C). The principal study involved the continuous intravenous administration of Ara-C to dogs to evaluate the toxicity when the total dose and duration of dose were varied. In addition, the toxicity of Ara-C was investigated following split doses or repeated intravenous administration. For comparative purposes the toxicity of cytosine arabinoside triacetate and uracil arabinoside hydrochloride (Ara-C Triacetate and Ara-U, respectively) were investigated in limited studies following a single continuous intravenous infusion. In each investigation the criteria of effect evaluated were: appearance, behavior, body weight, survival, hematologic and biochemical parameters, and gross and microscopic pathology. (Author)