Clinical Study on the Immunizing Capacity of Various Influenza Virus Vaccines

摘要

During the period covered the laboratory work on the normal population subjects was completed. The serologic response to the monovalent B/Hong Kong vaccines (Wyeth subviron and MSD whole virus) were similar. The nasal antibody response to these vaccines were also similar. The study on the chronic pulmonary disease patients was completed. Two vaccines were compared: Wyeth subviron bivalent (A/Port Chalmers, B/Hong Kong) unactivated vaccine and Lilly whole virus, zonal centrifuged bivalent (A/Port Chalmers, B/Hong Kong) inactivated vaccine. The A/Port Chalmers antigens were good antigens in both vaccines, but did not differ significantly. The B/Hong Kong antigens in both vaccines were relatively poor antigens and did not differ significantly. Nasal antibody responses were similar in both vaccines. There was little reactivity to the two vaccines, eliciting some reaction in over 50% of the subjects receiving each vaccine, but causing no serious reactions. There was no significant difference in the reactivity of the two vaccines.