monovalent influenza vaccine composition, kit, method for producing an influenza vaccine composition for a pandemic or prepandemic situation, and uses of an influenza virus antigen or antigen preparation thereof and an adjuvant in an oil-in-water emulsion, a pandemic influenza virus antigen or antigen preparation of the influenza virus hemagglutinin antigen, a pandemic influenza virus or antigenic preparation thereof, and an oil-in-emulsion adjuvant water and an antigen or antigen preparation of a first strain of influenza

摘要

monovalent influenza vaccine composition, kit, method for producing an influenza vaccine composition for a pandemic or pre-pandemic situation, and uses of an influenza virus antigen or antigen preparation thereof and an adjuvant in an oil-in-water emulsion, a pandemic influenza virus antigen or antigenic preparation of the influenza virus hemagglutinin antigen and an oil-in-water emulsion adjuvant and an antigen or antigenic preparation of a first strain of Influenza The present invention relates to monovalent influenza vaccine formulations and vaccination regimens for immunization against influenza disease, their use in medicine, in particular their use in enhancing immune responses to various antigens, and to methods of preparation. In particular, the invention relates to monovalent influenza immunogenic compositions comprising an influenza antigen or antigen preparation thereof from an influenza virus strain that is associated with a pandemic outbreak or has the potential to be associated with an outbreak. A pandemic compound in combination with an oil-in-water emulsion adjuvant comprising a metabolizable oil, a sterol or a tocopherol such as alpha-tocopherol, and an emulsifying agent.