Hemocompatibility Evaluation of Biomaterials

摘要

The stagnation point flow experiment was applied to study ex-vivo blood material interactions using 29 chemically different materials supplied by NIH contractors as potential blood contact surfaces. A total of 2250 valid tests were performed under this contract using the canine model. The results can be summarized as follows: (1) initial platelet adhesion is independent of surface chemistry; (2) all materials thrombose rapidly in regions of low flow at physiological temperatures; (3) the predominant cause of failure on most materials was the presence of roughness elements on their surfaces; and (4) cell aggregates are more loosely attached in some materials than in others. In parallel with the biomaterials evaluation, the feasibility of a long-term in vivo test procedure involving the intra-aortic magnetic suspension of a test device was demonstrated. The system was tested under simulation in vitro, and during exploratory in vivo experiments.