Carcinogenic Activity Associated with Asphaltic and Coal Tar Coatings Used in Potable Water Mains

摘要

Carcinogenic response was assessed with 0.2 ml of 4 asphaltic and 3 coal tar based paints applied topically in acetone to the shaved back of female SENCAR mice. Two weeks later a promotion schedule involving application of 1 microgram of TPA in acetine 3 x weekly to the back was instituted. Results after 12 weeks showed significantly increased numbers of papillomas with all products. In general coal tar products gave rise to 20 to 80 times the tumor response observed with asphaltic based products.