Het Effect van Dopamine op het Voorkomen van Nierlesies Veroorzaakt Door Hypotensie in Ratten (Effect of Dopamine on the Occurrence of Kidney Lesions Caused by Hypotension in Rats)

摘要

Dopamine at dose rates varying from 80 micrograms/kg/min to 0.3 micrograms/kg/min was infused i.v. in rats anesthetized with ketamine, during a period of 60 min while the rats were bled into a reservoir against a pressure of 50 mmHg. The bleeding was followed by reinfusion of the blood remaining in the reservoir at 60 min. At a dose rate of 80 micrograms/kg/min 5/9 animals died during the bleeding and the remaining 4 died within 24 hr. In all 9 animals the time at which the bleeding volume reached its maximum (tMBV in.) was shortened considerably and spontaneous uptake of shed blood started earlier than in the controls.