Method for Tracing Oxygen-18 In vivo: Application to Ozone Dosimetry in Animals

摘要

Data on ozone dosimetry in tissues would assist in validating models of extrapolation used in risk assessments. The paper presents some of the first measurements of ozone reaction products in mouse, rat and rabbit respiratory tissues after exposure to oxygen-18 labeled ozone (18O3). Exposure of mice, rats and rabbits to (18)O3 (1.0 ppm, 1 hr) caused enrichments as high as 15 micromoles (18)O/mole of total oxygen in the whole lung homogenates. Enrichments of 45-55 micromoles (18)O/mole were seen in alveolar macrophages and the lung surfactant pellet of rabbits.