Mutagenic Activity of Methacrylate Acid, N-butyl Ester in the Salmonella/microsome Assay with Attachments and Cover Sheet dated 061289.

摘要

The mutagenicity of methacrylic acid, n-butyl ester was evaluated in Salmonella tester strains TA98, TA100, TA1535, TA1537, and TA1538 (Ames Test), both in the presence and absence of added metabolic activation by Aroclor-induced rat liver S9 fraction. Based on the results of preliminary bacterial toxicity testing, the material was tested for mutagenicity at concentrations of 0, 60, 120, 180, 240, and 300 ug/plate using the direct plate incorporation method. Methacrylic acid, n-butyl ester did not cause a reproducible positive response in any of the bacterial tester strains, either in the presence or absence of added metabolic activation.