Developmental Changes in Mouse: Mercury Retention, Metabolism, and Excretion after Methylmercuric Chloride Administration

摘要

The developmental change in Hg retention after MeHgCl administration has been characterized in terms of timing, dosage effects, tissue distribution, routes of Hg excretion, and form of Hg excreted. Age-dependent changes in MeHg demethylation and fecal Hg excretion have been observed. These developmental changes in distribution and excretion affect MeHg risk assessment, and provide insights into possible mechanisms of MeHg metabolism and excretion. (ERA citation 04:055625)