Design of Tc-99M Generators: 1. Physicochemical Aspects

摘要

The two main aims in the development of a Tc-99m generator are: (A) the adsorption of large amounts of parent Mo-99 onto a chromatographic column, accompanied by low breakthrough (low activity of Mo-99 per unit activity of daughter Tc-99m in the eluate), and (B) efficient elution of the Tc-99m from the column. The elution yield (activity of separated Tc-99m relative to that present in the generator) and the Tc-99m activity concentration (mCi Tc-99m per ml eluate) must be high and reproducible. In the present report the two aims are considered separately. The influence of chemical parameters such as the chemical forms of Mo used, concentrations, pH values, etc., and of physical parameters, especially those relating to the self-irradiation of the generator system are studied. Models which explain some important characteristics of the system are proposed. 19 refs., 5 figs., 1 tab. (ERA citation 11:020483)