Ranking of PAH (Polynuclear Aromatic Hydrocarbons) Carcinogenic Potencies

摘要

The proposed framework for the analysis of tumorigenicity data permits an independence from statistical models and simultaneously allows for a hierarchal approach to estimates of carcinogenic potency. The proposed framework makes no assumptions inferring that certain bioassays are more appropriate than others. It attempts to use all available data, and thereby provides a balance in the overall analysis by standardizing data for a test compound to the data for a reference compound and utilizing data of the central region of the resulting distribution as the summary statistic. This type of framework may be of value in guiding the development and interpretation of analytic measures. The results demonstrate a consistency in the ranking of the carcinogenic potencies of representative PAHs using information from the largest single source of toxicologic data in the public domain. Admittedly, these correlations will remain empirical relationships until the biological mechanisms are elucidated. 22 refs., 5 tabs. (ERA citation 13:019636)