Evaluation of Mechanisms of Localization of Radiogallium and Comparison with Other Tumor and Inflammatory Imaging Agents: Final Report, October 1, 1977-June 30, 1988.

摘要

This contract demonstrates the importance of energy spectral uniformity of Auger (gamma) cameras in nuclear imaging. A second goal was to determine the mechanism of radiogallium localization in tumor and infection and to attempt to improve the quality of radiogallium scans. The project succeeded in developing a computer based system for improving energy spectral uniformity in the gamma camera. During the period of development of this program, energy spectral uniformity became recognized by major camera manufacturers as an important parameter in determining image quality. These manufacturers subsequently incorporated many of the concepts explored in our research into spectral uniformity correction devices. The current, most popular, devices used in the gamma camera for this purpose are integrated circuit based systems which actually replace the computer correction system used in our original development. In the area of radiogallium imaging, we were able to demonstrate the importance of iron binding proteins such as lactoferrin and iron binding micromolecules such as siderophores in the localization of gallium at sites of tumor or inflammation. We were also able to demonstrate the importance of the transferrin receptor in the localization of radiogallium in some tumors. Numerous ancillary experiments done under this contract also aided in the clinical application of radiogallium to the staging of various tumors and in the detection of inflammatory disease. 60 refs., 4 figs. (ERA citation 13:055087)