Treatment of Retinal Injuries by Low-Energy Laser; Models of Neurodegeneration inRetinal Injuries and Treatment by Low Energy Laser

摘要

We have demonstrated in previous studies that low energy laser reduces injury-induced deficits caused by acute partial injury of the rat optic nerve. The results of in-depth analysis suggest that the laser effect in this model is of a neuroprotective nature. We have devoted the time lapsed since approval of funding of the present study to characterization of the optic nerve partial lesion model, in an attempt to determine whether the progressive degeneration which occurs subsequently to the primary insult and continues in the absence of any external insult, is of a self-perpetuating nature, and whether such progressive degeneration follows any topographical pattern and whether any such pattern might be a reflection of the severity of the primary injury itself. By clarify the above points, we may turn our model into an ideal model for studying the neuroprotection of the optic nerve and retinal ganglion cells from injurious conditions.