Effect of Time of Menstrual Cycle on Drug Pharmacokinetics and Pharmacodynamics.

摘要

Gender has been shown to influence a number of pharmacokinetic variables including, serum protein binding (1), absorption rate (2), peak plasma concentration and area under the curve (3), and drug clearance (4) - A number of factors may contribute to gender differences in drug disposition including, differences in body composition, the use of oral contraceptives, plasma levels of the sex hormones, and the phases of the menstrual cycle (5,6). To date very few studies have actually examined the effects of the time of the menstrual cycle (follicular, ovulatory, luteal) on the pharmacokinetics and concomitant pharmacodynamics of a drug.