Analysis of Genes Differentially Expressed in a Human Ovarian Cancer Model.

摘要

Most epithelial cell cancers (cervix, colon, skin, prostate, breast, etc.) develop from precursor lesions resulting from an accumulation of mutations in growth regulatory genes. Such precursor lesions have not been identified for OVCA but it has been proposed that OVCAs arise by a multistep process through increasingly aggressive stages. We have shown that immortalized human ovarian surface epithelial (HOSE) cells undergo stepwise progression to the malignant phenotype in vitro. We now hypothesize that this phenotypic presentation reflects changes in the expression of genes in biochemical pathways required for transition from benign cells to malignantly transformed cells. The long-range goal of these studies is to identify aberrantly expressed genes in NOSE cells at various stages along the path to the malignant phenotype for the purpose of characterizing biochemical pathways whose expression is dysregulated.