Magnetic Resonance Arterial Spin Tagging for Non-Invasive Pharmacokinetic Analysis of Breast Cancer.

摘要

This research project focused on the development of MRI arterial spin tagging to non- invasively measure breast tissue perfusion. The specific aims were to (1) refine arterial spin tagging pulse sequences, (2) develop automated data analysis software, and (3) compare the technique to first-pass contrast- enhanced MRI and biopsy. New spin-tagging pulse sequences were developed for the GE 1.5T Advantage and Horizon LX CV/I MRI systems, and new image processing software, including software for statistical analysis of spin tagging and contrast enhanced dynamic scans, were written for use in the clinical setting. Year three and no-cost extension years of the project focused on clinical comparison of arterial spin tagging with first-pass, contrast-enhanced MRI in patients with unbiopsied breast masses, for aim.