Non-Invasive Screening for Breast Cancer Biomarkers in Nipple Aspirates by Mass Spectrometry

摘要

The three challenges that we faced before are: (1) To consistently differentiate peak differences in NA detected by Surface-Enhance Laser Desorption/Ionization (SELDI) between the two groups of women: breast cancer vs. non- cancer; (2) To identify and characterize the peak proteins that are differentially expressed in cancerous and non-cancerous NA; (3) To develop software program that can consistently identify the true peak from noise and quantify the intensity of each peak in a reproducible fashion.