Optical Transillumination Spectroscopy of Breast Tissue to Determine the Cancer Risk in Pre- and Post-Menopausal Women

摘要

The objective of this study is to demonstrate a correlation between non-invasive optical transillumination spectroscopy and parenchymal density pattern, which are know to provide the highest odds ration for the risk of developing breast Cancer. The study includes pre- and post-menopausal women. Initial results indicate that optical transillumination spectroscopy can differentiate between high and low parenchymal density with sensitivity and specificity > 90 for the study group (n= 225), after the introduction of stratification for the position on the breast. Additional analysis models the percent dense tissue area from the measured transillumination spectrum. A separate study investigates the influence of the menstrual cycle upon the transillumination spectra and no significant effects are noted.