Integration of Analytic and Synthetic Biosystem Models and Data

摘要

This effort, funded under DARPA's Biocomputing (BioComp) program, was directed at providing data services for the BioSpice infrastructure. BioSpice is an environment akin to the Electrical Engineering SPICE modeling and simulation package, in which an open environment and standards-based modularity enable an enormous range of tools for the development and understanding of electronic circuits to be applied without restrictions resulting from proprietary or closed interfaces. BBN also teamed with the University of Pennsylvania to develop an intuitive tool called BioSketchpad, for creating and parameterizing models and connecting the resulting models to a simulator. A modeling language (Systems Biology Markup Language (SBML)), was also developed for representing interesting molecular biology models and to support model interchange between different tools. The SBML effort required collaboration with a separate systems biology development effort (which had created the first version of SBML) that was an outgrowth of other research efforts.