Bisphosphonate-Based Contrast Agents for Radiological Imaging of Microcalcifications

摘要

An optical imaging system was developed to allow the visualization of novel NIR-tagged radiological contrast agents. A fluorophore-tagged ligand based on alendronate sodium was developed and tested in mice. The system showed strong affinity for physiological calcium and could be further developed as a radiological contrast agent for x-ray mammography.