Precision Targeting With a Tracking Adaptive Optics Scanning Laser Ophthalmoscope

摘要

Precise targeting of retinal structures including retinal pigment epithelial cells, feeder vessels, ganglion cells, photoreceptors, and other cells important for light transduction may enable earlier disease intervention with laser therapies and advanced methods for vision studies. A novel imaging system based upon scanning laser ophthalmoscopy (SLO) with adaptive optics (AO) and active image stabilization was designed, developed, and tested in humans and animals. An additional port allows delivery of aberration-corrected therapeutic/stimulus laser sources. The system design includes simultaneous presentation of non-AO, wide-field (tilde 40 deg) and AO, high-magnification (1- 2 deg) retinal scans easily positioned anywhere on the retina in a drag-and- drop manner. The AO optical design achieves an error of.