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Chemoprevention Against Breast Cancer with Genistein and Resveratrol; Annual summary, 25 Feb 2005-24 Feb 2008

机译:金雀异黄素和白藜芦醇对乳腺癌的化学预防;年度总结,2005年2月25日至2008年2月24日

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Breast cancer remains a destructive disease despite new therapeutics. It is well accepted that environmental factors can play an important role in determining one's future risk of the disease. We believe that two natural polyphenols, genistein (a component of soy) and resveratrol (a component of grapes and red wine), can suppress mammary carcinogenesis. We and others have clearly shown mammary-protective effects against chemically-induced cancer. This project aimed to elucidate mechanisms through which these polyphenols may exert their effects. We show that genistein and resveratrol modulate the gene and protein expression of several critical players in the mammary gland involved in growth and proliferation. We see changes in MAPK signaling pathway, the PI3K/Akt pathway, apoptotic cascade, beta casein, as well as changes in sex steroid receptor co-activators. We have demonstrated that the estrogen receptors play an important role in the mechanisms of genistein and resveratrol. These data will add to the pre-clinical data necessary to forward further work with these polyphenols towards the prevention of breast cancer.

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