Development of Microdevices for Biomolecular Detection; Final rept. 1 Feb 2004-31 Dec 2007

摘要

Biosensors suitable for providing informed rapid treatment analysis for soldiers and real-time environmental monitoring of toxic agents were developed. In particular, glass encapsulated field-effect sensors that are chemically robust and batch-fabricated by a conventional 6' wafer process were developed and demonstrated for the following applications: (i) Polymerase Chain Reaction (PCR) product quantification, (ii) Integrated microelectronic device for label-free nucleic acid amplification and detection, and (iii) Monitoring of heparin and its low molecular weight analogs.